In the late 1600s Scotland, in an attempt to start an international trade empire, founded a small settlement in what is now modern Panama. The venture was frustrated at every turn by the English, who did not want their northern neighbor competing on the international scene, and the Panamanian jungle proved to be an inhospitable environment. The settlers were plagued by starvation and malaria, and eventually the Scots were ousted by the Spanish.
The dramatic failure of the colony led to the end of Scottish independence, and a few years later 1707 that country would permanently join with England. Had the colony succeeded, the map of Europe and Central America could look very different today, but as it is Scottish ambitions and independence vanished hundreds of years ago in the jungles of Central America.